{"created":"2023-05-15T14:45:26.519967+00:00","id":535,"links":{},"metadata":{"_buckets":{"deposit":"e79b7420-3a04-4ff6-8d0d-ebad7935f159"},"_deposit":{"created_by":13,"id":"535","owners":[13],"pid":{"revision_id":0,"type":"depid","value":"535"},"status":"published"},"_oai":{"id":"oai:k-junshin.repo.nii.ac.jp:00000535","sets":[]},"author_link":["2511","2507","2512","2508","2509","2510"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"105","bibliographicPageStart":"91","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"研究紀要"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"酒匂, 麻紀子"}],"nameIdentifiers":[{"nameIdentifier":"2507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀬戸口, 賀子"}],"nameIdentifiers":[{"nameIdentifier":"2508","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"サコウ, マキコ"}],"nameIdentifiers":[{"nameIdentifier":"2509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"セトグチ, ヨシコ"}],"nameIdentifiers":[{"nameIdentifier":"2510","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakoh, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Setoguchi, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2512","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"　肝臓で，コレステロールからの胆汁酸生合成をおこなう初発酵素である Cholesterol 7α-hydroxylase は，その mRNA 合成量に，夜間高く昼間低い遺伝子発現の日内リズムが見られ，そのリズムは摂食によって影響をうけることが知られている。\n　また肝臓で主として合成される，ケノデオキシコール酸とコール酸合成の分岐点に位置するCholesterol １２α-hydroxylase 酵素の mRNA 合成についても Cholesterol ７α-hydroxylase と同じような日内リズムがあり，摂食によるリズムの変動も弱いながら認められている。このような摂食による変動が現れる理由を明らかにするために，摂食時間を昼間に限定したウサギについて，最後に摂食させるかわりに，インスリンを投与し Cholesterol ７α-hydroxylase およびCholesterol １２α-hydroxylase の mRNA 合成の変動を見た。その結果， Cholesterol ７α-hydroxylase mRNA の合成はインスリン投与によって，摂食と同様に日内リズムの著しい逆転がみられ，また Cholesterol １２α-hydroxylase mRNA についても摂食により弱い日内リズムの逆転が観察された。この結果より，摂食による Cholesterol ７α-hydroxylase および Cholesterol\n１２α-hydroxylase の日内リズムの変動は，摂食により分泌されるインスリンの作用もその一因と推定される。","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00271490","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kagoshima Immaculate Heart College, Science of Living Department"},{"subitem_text_language":"en","subitem_text_value":"Kagoshima Immaculate Heart College, Science of Living Department"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"鹿児島純心女子短期大学生活学科"},{"subitem_text_value":"鹿児島純心女子短期大学生活学科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-07-31"}],"displaytype":"detail","filename":"kiyo_31_06.pdf","filesize":[{"value":"602.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"kiyo_31_06","url":"https://k-junshin.repo.nii.ac.jp/record/535/files/kiyo_31_06.pdf"},"version_id":"8f806741-4789-4427-b27c-1ff05ea24747"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol ７α-hydroxylase","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol １２α- hydroxylase","subitem_subject_scheme":"Other"},{"subitem_subject":"Circadian rhythm","subitem_subject_scheme":"Other"},{"subitem_subject":"Scheduled daily feeding","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol ７α-hydroxylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol １２α- hydroxylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Circadian rhythm","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Scheduled daily feeding","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cholesterol ７α-Hydroxylase 及び Cholesterol １２α-Hydroxylase mRNA の合成に対するインスリンの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cholesterol ７α-Hydroxylase 及び Cholesterol １２α-Hydroxylase mRNA の合成に対するインスリンの影響"},{"subitem_title":"Effects of Scheduled Daily Feeding Time and Insulin on the mRNA Synthesis of Cholesterol ７α-Hydroxylase and Cholesterol １２α-Hydroxylase","subitem_title_language":"en"}]},"item_type_id":"1","owner":"13","path":["93"],"pubdate":{"attribute_name":"公開日","attribute_value":"2001-03-01"},"publish_date":"2001-03-01","publish_status":"0","recid":"535","relation_version_is_last":true,"title":["Cholesterol ７α-Hydroxylase 及び Cholesterol １２α-Hydroxylase mRNA の合成に対するインスリンの影響"],"weko_creator_id":"13","weko_shared_id":-1},"updated":"2023-05-15T18:21:17.186282+00:00"}